D-Panthenol with CAS 81-13-0
What is D- Panthenol?
D-Panthenol is the biologically active dextrorotatory form of panthenol (Provitamin B5), widely used across cosmetics, pharmaceuticals, and nutraceuticals.
D-Panthenol (CAS 81-13-0), also known as Dexpanthenol or Provitamin B5, is a stable alcohol analogue of pantothenic acid. Upon absorption into the skin or body, it is oxidized to pantothenic acid (Vitamin B5), making it a valuable precursor in both topical and oral formulations.
As a highly hygroscopic humectant, D-Panthenol penetrates the skin barrier effectively, attracting and retaining moisture to deliver long-lasting hydration. Its proven wound-healing, anti-inflammatory, and conditioning properties make it one of the most trusted active ingredients in personal care, dermatology, and veterinary medicine. Runtai Chemical offers D-Panthenol in both liquid and white crystalline powder forms, with full documentation (COA, MSDS, TDS) and compliance with USP, EP, and food-grade standards.
Runtai Chemical is a professional and reliable China manufacturer of D-Panthenol with CAS 81-13-0 with CAS 56-12-2 with higher purity and lower price. If you are interested in our D-Panthenol, PLS free to contact us for a free sample!
Product Advantages
- Superior Moisturization: D-Panthenol is a powerful humectant that binds and retains moisture within the skin layers, significantly improving skin hydration, elasticity, and softness. Ideal for dry-skin treatments and anti-aging formulas.
- Deep Skin Penetration: Its small molecular size allows rapid and deep penetration through the stratum corneum, ensuring efficient delivery of active Vitamin B5 to deeper skin layers where it exerts its metabolic effects.
- Wound Healing & Repair: Stimulates fibroblast proliferation and accelerates epithelialization, supporting the natural wound-healing process. Widely used in post-procedure skincare, burn care, and dermatological ointments.
- Anti-Inflammatory Action: Reduces skin irritation, redness, and inflammation. Particularly beneficial in formulations targeting sensitive skin, atopic dermatitis, and post-sunburn recovery.
- Hair Conditioning & Strength: D-Panthenol coats the hair shaft, improving strength, shine, and combability. Reduces breakage and split ends. A staple active in shampoos, conditioners, and hair masks worldwide.
D-Panthenol Quick details
- Chemical Name:D- Panthenol
- CAS No.: 81-13-0
- EINECS: 201-327-3
- Molecular Formula: C9H19NO4
- Molecular weight: 205.25
- Appearance:Colorless or light yellow transparent liquid
- Assay:75%min;98%min
- Synonyms:4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;BepantheChemicalbookn;Bepanthene;Bepantol;Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(R)-
D-Panthenol Typical Properties
| Item | Specification | Results |
| Appearance | Colorless or faintly yellow transparent liquid | Conforms |
| Identification | Positive reaction | Positive reaction |
| Purity | 75.0%～78.5% | 76.7% |
| Water determination | ≤25% | 20.1% |
| Specific optical rotation | +29.0° ～+31.5° | 30.3° |
| Limit of aminopropanol | ≤1.0% | <1.0% |
| Residue on ignition | ≤0.1% | 0.02% |
| Heavy metals | ≤20ppm | Conforms |
| Conclusion | The results conforms with enterprise standards | |
| Item | Specification | Results |
| Appearance | Clear,viscous, somewhat hygroscopic liquid. Some crystallization may occur on standing | Conforms |
| Solubility | Freely soluble in water ,in alcohol , in
methanol ,and in propylene glycol ;soluble in chloroform and in ether ;slightly soluble in glycerin ;practically insoluble in heptane. |
Conforms |
| Identification | ||
| A:Infrared absorption < 197F> | Conform to USP2021 | Conforms |
| B: The Sample solution： | C:The Sample solution ： | Conforms |
| C:The Sample solution ： | a purplish red color develops | Conforms |
| Assay | 98.0%～102.0% | 99.3% |
| Water determination | ≤1.0% | 0.1% |
| Specific optical rotation | +29.0° ～+31.5° | 30.3° |
| Limit of aminopropanol | ≤1.0% | 0.62% |
| Residue on ignition | ≤0.1% | 0.02% |
| Refractive Index 20℃ | 1.495～1.502 | 1.497 |
| Conclusion | The results conforms with USP2021 standards | |
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D-Panthenol Applications
Cosmetics & Personal Care
- Skincare: Acts as a potent moisturizer, enhancing skin hydration, reducing transepidermal water loss (TEWL), and improving skin barrier function. It also soothes inflammation, reduces redness and itching, and promotes wound healing, making it suitable for sensitive, dry, or damaged skin.
- Haircare: Penetrates hair shafts to repair damaged cuticles, reduce split ends, increase hair shine and softness, and strengthen hair elasticity.
Pharmaceuticals
- Used in topical formulations for treating burns, wounds, ulcers, and dermatitis, accelerating tissue regeneration and reducing scarring.
- Serves as a vitamin B5 precursor in oral supplements to support metabolic processes, maintain skin and mucous membrane health, and boost immunity.
Food & Feed
- Added as a nutritional supplement to food and animal feed to enhance protein, fat, and carbohydrate metabolism, improve growth, and promote healthy skin and fur in animals.
D-Panthenol Package & Storage
- Package: 25KG/drum;1000kg/ibc drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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