Benfotiamine with CAS 22457-89-2
What is Benfotiamine?
Benfotiamine (S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble (lipophilic) derivative of Thiamine — commonly known as Vitamin B1. Unlike water-soluble thiamine, Benfotiamine penetrates cell membranes more effectively, resulting in significantly higher bioavailability and longer retention in the body.
First synthesized in Japan in the 1960s, Benfotiamine has since become a well-researched active pharmaceutical ingredient (API) with extensive clinical applications — especially in supporting metabolic and neurological health.
Runtai Chemical is a professional and reliable China manufacturer of Benfotiamine with CAS 22457-89-2 with higher purity and lower price. If you are interested in our Benfotiamine, PLS free to contact us for a free sample!
Product Advantages
- Superior Bioavailability: Its fat-soluble nature enables direct absorption through cell membranes without active transport mechanisms.
- Enhanced Neuroprotection: Elevates thiamine pyrophosphate (TPP) levels in nerve tissue, reducing oxidative stress and glycation end-products.
- Metabolic Support: Activates the pentose phosphate pathway, reducing the accumulation of advanced glycation end-products (AGEs).
- Excellent Formulation Stability: Greater stability compared to thiamine HCl. Maintains potency under a wider range of pH and temperature conditions, extending shelf life in finished dosage forms.
Benfotiamine Quick details
- Chemical Name:Benfotiamine
- CAS No.: 22457-89-2
- EINECS: 245-013-4
- Molecular Formula:C19H23N4O6PS
- Molecular weight:466.45
- Appearance: White crystal or white crystalline powder
- Synonyms:berdi;betivina;benphothiamine;BENFOTAMINE(S-BENZOYLTHIAMINE-O-MONOPHOSPHATE);S-[2]-[(4-Amino-2-methyl-5-pyrimidinyl)methy-[formylamino]-1-[2-phosphonoxy)ethyl]-1-propenyloicesterphenylcarbathionoicacid;ThiobenzoicacidS-[2Chemicalbook-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propenyl]ester;ThiobenzoicacidS-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-5-(phosphonooxy)-2-penten-3-yl]ester;Benfotiamine
Benfotiamine Typical Properties
| Item | Specification | Results |
| Description
|
White crystal or white crystalline powder
|
White crystalline
powder
|
| Identification | The retention time of main peak is
accordant with that of Benfotiamine RS
|
conforms |
| Melting point
|
≥198℃
|
203~206℃
|
| Loss on drying
|
≤1.2%
|
0.4%
|
| Clarity and color of solution
|
Colorless to light yellow clear solution
|
Colorless and clear solution
|
| Chloride
|
≤0.053%
|
<0.053%
|
| Sulphate
|
≤0.011%
|
<0.011%
|
| Heavy metals
|
≤20ppm
|
<20ppm
|
| Cd
|
≤1ppm
|
0.042ppm
|
| As
|
≤1ppm
|
<0.01ppm
|
| Pb
|
≤0.5ppm
|
<0.02ppm
|
| Hg
|
≤0.3ppm
|
<0.005ppm
|
| Bulk density
|
≥0.35g/ml
|
0.50g/ml
|
| Thiamine
|
≤0.1%
|
0.09%
|
| Benzoic acid
|
≤0.1%
|
0.01%
|
| Total impurities
|
≤0.1%
|
0.3%
|
| Assay
|
98.0%-102.0%
|
100.8%
|
| Total Plate Count
|
≤1000CFU/g
|
＜10CFU/g
|
| Yeast & Mold
|
≤100CFU/g
|
＜10CFU/g
|
| Salmonella
|
Negative
|
Negative
|
| E.Coli
|
Negative
|
Negative
|
| Staphylococcus Aureus
|
Negative
|
Negative
|
| Conclusion | The results conforms with enterprise standards | |
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Benfotiamine Applications
- Pharmaceutical: Used as an API in prescription drugs and OTC products targeting diabetic peripheral neuropathy, Wernicke’s encephalopathy, thiamine deficiency, and Alzheimer’s disease.
- Dietary Supplements & Nutraceuticals: Widely used in high-potency B-vitamin complexes, nootropic stacks, anti-aging supplements, and metabolic wellness products. Popular in European and North American supplement markets.
- Functional Food & Beverage: Added to fortified foods, energy drinks, and meal replacement products. Its lipid solubility enables incorporation into oil-based food matrices where standard thiamine performs poorly.
- Veterinary Applications: Used in animal nutrition and veterinary medicine to address thiamine deficiencies in livestock, poultry, and companion animals. Superior tissue penetration ensures faster clinical response.
- Cosmeceuticals: Emerging use in topical skincare formulations targeting glycation-induced skin aging. Benfotiamine’s ability to inhibit AGE formation supports anti-wrinkle and skin-brightening products.
Benfotiamine Package & Storage
- Package:1kg/bag; 25kg/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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