Dimethyl Isosorbide with CAS 5306-85-4
What is Dimethyl Isosorbide(DMI)?
Dimethyl Isosorbide (DMI), systematically named 1,4:3,6-dianhydro-2,5-di-O-methyl-D-glucitol, is a bicyclic ether solvent synthesized from sorbitol, a plant-derived sugar alcohol. Its CAS number is 5306-85-4, and it belongs to the isosorbide family of renewable bio-based chemicals.
What makes DMI exceptional among solvents is its amphiphilic molecular architecture — the isosorbide scaffold gives it simultaneous hydrophilic and lipophilic character. This allows DMI to bridge water-based and oil-based formulation systems, dissolving a broad spectrum of active ingredients in a single phase.
DMI is well-established as a cosmetic-grade and pharmaceutical-grade excipient with extensive safety data. It is non-toxic, non-mutagenic, and fully biodegradable.
Runtai Chemical is a professional and reliable China manufacturer of Dimethyl Isosorbide with CAS 5306-85-4 with higher purity and lower price. If you are interested in our Dimethyl Isosorbide, PLS free to contact us for a free sample!
Product Advantages
- Bio-Based & Sustainable: Derived from sorbitol (corn/sugarcane origin), DMI is a renewable, plant-sourced solvent. Fully biodegradable and REACH-compliant.
- Superior Penetration Enhancement: DMI dramatically improves transdermal and trans-follicular delivery of active ingredients.
- Exceptional Solvency Power: DMI’s unique amphiphilic structure dissolves both hydrophilic and lipophilic compounds.
- Outstanding Safety Profile: Non-toxic, non-sensitizing, non-mutagenic. DMI has passed extensive in vitro and in vivo safety studies and is accepted in cosmetic and topical pharmaceutical formulations globally.
- Superior Skin Aesthetics: Formulations with DMI exhibit a lightweight, non-greasy, fast-absorbing skin feel.
Dimethyl Isosorbide Description
- Chemical Name: Dimethyl Isosorbide
- CAS No.: 5306-85-4
- EINECS: 226-159-8
- Molecular Formula: C8H14O4
- Molecular weight: 174.2
- Appearance: Colorless transparent liquid
- Synonyms: ISOSORBIDEDIMETHYLETHER;2,5-DI-O-METHYL-1,4:3,6-DIANHYDRO-D-GLUCITOL;1,4:3,6-DIANHYDRO-2,5-DI-O-METHYL-D-GLUCITOL;1,4:3,6-DIANHYDRO-2,5-O-DIMETHYL-D-GLUCITChemicalbookOL;1,4:3,6-DIANHYDROSORBITOL2,5-DIMETHYLETHER;-3,6-Dimethoxyhexahydrofuro[3,2-b]furan;Isosorbidedimethylether(DimethylIsosorbide);Dimethylisosorbide99%(DMI)
Dimethyl Isosorbide Typical Properties
| Item | Specification | Results |
| Character | Colorless transparent liquid | Conforms |
| Water | ≤0.1% | 0.02% |
| Specific gravity(25℃）g/ml
|
1.15-1.17 | 1.1600 |
| Refractive Index
|
1.450-1.470 | 1.4610 |
| Sulfatbd Ash | ≤0.2% | 0 |
| acid value mgKOH/g | ≤1.5 | 0.070 |
| Purity | ≥99.0% | 99.42% |
| Conclusion | The results conforms with company standards | |
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Dimethyl Isosorbide Applications
- Cosmetics & Personal Care: DMI is a premium solvent and active-delivery agent in high-performance skincare. It solubilizes retinol, niacinamide, alpha-arbutin, and peptides, improving bioavailability and texture. Used in serums, sunscreens, anti-aging creams, whitening formulas, toners, and professional hair treatments.
- Pharmaceutical & Topical Drug Delivery: As a pharmaceutical excipient, DMI enhances transdermal bioavailability of APIs, including NSAIDs, antifungals, corticosteroids, and hormone therapies. Reduces effective dosage and minimizes systemic side effects in topical formulations.
- Agrochemicals: DMI improves foliar absorption of herbicides, fungicides, and plant growth regulators. As a co-solvent and adjuvant, it increases crop protection efficacy while reducing active ingredient requirements — supporting sustainable agriculture.
- Industrial & Specialty Chemicals: DMI serves as a low-VOC, high-boiling co-solvent in industrial coatings, polymer resins, adhesives, and specialty cleaning agents. A safer alternative to conventional petrochemical solvents such as NMP and DMF.
Dimethyl Isosorbide Package & Storage
- Package:25kg/drum; 200kg/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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