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DBU – 1,8-Diazabicyclo [5.4.0]undec-7-ene with CAS 6674-22-2
What is DBU?
DBU, formally known as 1,8-Diazabicyclo[5.4.0]undec-7-ene, is a bicyclic amidine compound and one of the most powerful commercially available non-nucleophilic organic superbases. DBU effectively deprotonates substrates that are otherwise resistant to conventional amine bases.
Unlike typical amine bases, DBU’s nitrogen lone pair is sterically shielded within its bicyclic ring system. This unique architecture allows it to act as an extremely strong base while exhibiting negligible nucleophilicity — making it invaluable in reactions where competing nucleophilic pathways must be avoided.
Runtai Chemical is a professional and reliable China manufacturer of DBU – 1,8-Diazabicyclo [5.4.0]undec-7-ene with CAS 6674-22-2 with higher purity and lower price. If you are interested in our DBU, PLS free to contact us for a free sample!
Product Advantages
- Extreme Basicity: DBU is a true superbase, capable of deprotonating substrates including weak C–H acids, terminal alkynes, and activated methylene compounds efficiently under mild conditions.
- Non-Nucleophilic Character: The bicyclic ring system sterically shields the nitrogen lone pair, preventing DBU from acting as a nucleophile. This allows clean deprotonation without unwanted side reactions or substitution products.
- Thermally Stable & Recyclable: DBU is stable at elevated temperatures and its conjugate acid (DBUH⁺ salt) can often be recovered and regenerated, offering process efficiency benefits in large-scale manufacturing.
- Wide Solubility Profile: Fully miscible with most common organic solvents — DMF, THF, DCM, DMSO, acetonitrile, toluene — ensuring seamless integration into diverse reaction systems and workup procedures.
DBU Quick details
- Chemical Name:1,8-Diazabicyclo-5,4,0-Undecene-7
- CAS No.: 6674-22-2
- EINECS: 229-713-7
- Molecular Formula: C9H16N2
- Molecular weight: 152.24
- Appearance:Colorless or light yellow transparent liquid
- Assay: 99%min
- Synonyms:1,5-DIAZABICYCLO(5,4,0)UNDEC-5-ENE;1,8-DIAZABICYCLO[5,4,0]-7-UNDECENE;1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE;1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE(1,5-Chemicalbook5);1,8-DIAZABICYCLO(5,4,0)UNDECENE-7;1,8-DIAZEBICYCLO[5.4.0]UNDEC-7-ENE;1,8-Diazabicyclo[5.4.0]undecane-7-ene;1,8-Diazabicyclo(5x4x0)undec-7-ene
DBU Typical Properties
| Item | Specification | Results |
| Appearance | Colorless or light yellow
transparent liquid |
Conforms |
| Assay | ≥99% | 99.62% |
| Water | ≤ 0.5% | 0.20% |
| Conclusion | The results conforms with enterprise standards | |
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DBU Applications
- Pharmaceutical Synthesis: DBU serves as a base in synthesis of APIs, including β-lactam antibiotics, nucleoside analogues, and heterocyclic scaffolds.
- Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides. DBU facilitates key bond-forming steps in active ingredient production where selectivity and yield are critical.
- Polymer & Material Chemistry: Catalyst for ring-opening polymerization (ROP) of cyclic esters and carbonates to produce biodegradable polymers (PLA, PCL). Also used in organocatalytic polycarbonate synthesis.
- Specialty Fine Chemicals: Widely applied as a base catalyst in synthesis of dyes, fragrances, lubricant additives, and other specialty chemicals requiring controlled deprotonation chemistry.
DBU Package & Storage
- Package: 200KG/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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