Ectoine with CAS 96702-03-3
What is Ectoine?
Ectoine (CAS 96702-03-3) is a naturally occurring cyclic amino acid derivative first isolated from the extremophilic bacterium Halorhodospira halochloris. Chemically known as (S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid, it belongs to the class of “extremolytes” — bioprotective molecules that shield living cells from extreme environmental conditions.
Ectoine functions as a compatible solute: it accumulates inside cells without disrupting biochemical processes, instead forming a highly ordered hydration shell around proteins, nucleic acids, and membrane structures. This unique mechanism protects against osmotic stress, heat, dehydration, UV radiation, and oxidative damage.
In commercial applications, Ectoine has become a premier active ingredient in cosmetics, dermatology, pharmaceutical formulations, and biotechnology — valued for combining safety, efficacy, and natural origin.
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Product Advantages
- Superior Moisture Retention: Ectoine creates a stable hydration shell around skin cells and proteins through its water-structuring mechanism.
- Cell & Membrane Protection: Protects cellular membranes, proteins, and DNA from environmental stressors including UV radiation, heat shock, and oxidative damage.
- Natural & Biocompatible: Derived from naturally occurring extremophilic bacteria. Non-toxic, biodegradable, and well-tolerated by human skin and biological systems.
- Protein & Enzyme Stabilization: Stabilizes enzymes, vaccines, and therapeutic proteins against aggregation and denaturation during storage and processing.
- Anti-Inflammatory Action: Clinical evidence demonstrates that Ectoine reduces inflammatory responses triggered by UV exposure and allergens.
- UV Photoprotection: Ectoine stabilizes protein and nucleic acid structures against UV-induced damage, functioning as a molecular photoprotectant.
Ectoine Quick details
- Chemical Name: Ectoine
- CAS No.: 96702-03-3
- EINECS: 431-910-1
- Molecular Formula: C6H10N2O2
- Molecular weight:142.16
- Appearance: White crystalline powder
- Synonyms:(S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLICACID;THP[B];ECTOINE;4-Pyrimidinecarboxylicacid,1,4,5,6-tetrahydro-2-methyl-,(4S)-(9CI);(S)-1,4,5,6-Tetrahydro-2-mChemicalbookethyl-4-pyrimidinecarboxylicacid;NSC614616;Thp(B),(S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylicacid;(4S)-2-METHYL-1,4,5,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLICACID, Ectoin, NSC 614616, Pyrostatin B, THP(B)
Ectoine Typical Properties
| Item | Specification | Results |
| Appearance | White powder | White powder |
| Purity | ≥99% | 99.85% |
| Specific Rotation | +139°～+145° | +140.3° |
| PH | 6.0-8.0 | 7.0 |
| Loss on drying | ≤0.5% | 0.07% |
| Sulfuric acid ash | ≤0.3% | 0.02% |
| Chloride | ≤0.01% | Conforms |
| Total colones | ≤100CFU/g | Conforms |
| Molds and yeasts | ≤50CFU/g | Conforms |
| Escherichia coli | Negative | Not detected |
| Staphylococcus | Negative | Not detected |
| Cd | ≤5ppm | Conforms |
| As | ≤2ppm | Conforms |
| Pb | ≤10ppm | Conforms |
| Hg | ≤1ppm | Conforms |
| Conclusion | The results conforms with enterprise standards | |
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Ectoine Applications
- Cosmetics & Skincare: Anti-aging creams, sunscreens, moisturizers, serums, and sensitive skin formulations. Recognized as a high-performance cosmetic active by INCI.
- Pharmaceuticals: Nasal sprays for allergic rhinitis, topical creams for atopic dermatitis, ophthalmic solutions for dry eye, and excipient in biologic drug formulations.
- Biotechnology: Enzyme and diagnostic reagent stabilizer, PCR additive, vaccine preservation, and protein formulation excipient for biotech manufacturing.
- Hair Care: Shampoos, conditioners, and scalp treatments that protect hair follicle cells and improve moisture balance under heat and styling stress.
- Ophthalmic Solutions: Eye drops formulated to protect corneal cells from desiccation and environmental stress — particularly dry eye syndrome and contact lens solutions.
- Nutraceuticals: Emerging cell-protective dietary supplement applications, leveraging Ectoine’s ability to stabilize cellular structures and reduce oxidative stress internally.
Ectoine Package & Storage
- Package:100g/bag; 25kg/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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