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On the path of seeking health and longevity, scientists constantly discover new substances and nutrients. Among them, pyrroloquinoline quinone (PQQ) and Coenzyme Q10(CoQ10) have attracted widespread attention from scientists due to their unique biological properties and health benefits for the human body.
What is Pyrroloquinoline quinone(PQQ)?
Pyrroloquinoline quinone (PQQ) is a crucial redox cofactor and antioxidant for human health. PQQ plays a very important role in human nutrition, it is the third type of coenzyme after nicotinamide (vitamin B3) and riboflavin (vitamin B2).
Compared with traditional antioxidants (such as vitamin C and E), PQQ neutralizes free radicals, reduces oxidative stress, and affects cell signaling and biological pathways in its unique way, thereby playing important functions such as antioxidant, anti-aging, and immune enhancement.
PQQ has received great attention in nutrition and pharmacology since its discovery in 1979. It can support the growth and development of mitochondria, stimulate rapid cell growth in the human body, possess strong antioxidant properties, help eliminate free radicals, and reduce cell damage. It has powerful effects on cardiovascular health, brain health, metabolic function, etc., mainly helping with physical recovery and anti-fatigue. PQQ has great potential in the field of anti-aging and is popular among people.
The benefits of PQQ for the body
1. Supports mitochondrial function and energy metabolism
Mitochondria are the ‘energy production factories’ in cells, continuously producing energy for our cells. As age increases, the number of healthy mitochondria in the body decreases.
PQQ, as an auxiliary factor, can promote mitochondrial regeneration in aging cells, increase the activity of related enzymes, and stimulate mitochondrial growth. Thereby increasing the energy level of organs, improving fatigue, and enhancing the body’s metabolic efficiency.
Therefore, it is believed to potentially bring health benefits such as improving energy utilization efficiency, supporting cellular function, and delaying aging-related processes.
2. Antioxidant and anti-inflammatory effects
The production and clearance of various free radicals in organisms should be in a dynamic balance; that is, the free radicals in the body should always be maintained at a certain level, and excessive or insufficient free radicals are detrimental to the body.
The strong antioxidant properties of PQQ are reflected in its ability to neutralize free radicals, reduce oxidative stress, and help protect cells from oxidative damage It also catalyzes repeated redox reactions to a large extent.
Its strong antioxidant properties can counteract destructive molecules that damage cells, thereby preventing damage to heart, brain, and skin cells. Under the same environment and conditions, PQQ can undergo 20000 catalytic conversions, while vitamin C can only undergo 4 conversions.
3. PQQ can protect nerve cells and improve cognition
Neuronal growth factor (NGF) is a small protein that protects existing neurons and encourages the growth of new neurons. It can repair damaged neuronal cells.
PQQ has been proven to stimulate the synthesis/secretion of NGF, promote the generation of neurotrophic factors without cytotoxicity, and therefore has potential benefits for improving memory, learning ability, and cognitive function.
Scientists have found that PQQ can help strengthen nerve cells in the body while studying the treatment of cognitive impairment and some dementia. In an environment containing PQQ, the peak synthesis of nerve cells, which is beneficial for neuronal development, can increase by 40 times.
4. Enhance cardiovascular health
PQQ can protect cells from oxidative stress damage, promote energy metabolism of myocardial cells, enhance cardiac and myocardial contractility, increase the elasticity and toughness of vascular walls, reduce scar tissue formation, and repair damaged vascular endothelium.
It can reduce the risk of thrombosis by inhibiting the excessive activation of procoagulant factors. At the same time, it can enhance the self-regulation ability of cerebral blood vessels, stabilize blood flow perfusion, and reduce brain ischemia or bleeding damage caused by blood pressure fluctuations
5. Improve sleep
Melatonin is a hormone that regulates the biological clock and is known to play a positive role in improving sleep disorders, emotional disorders, and enhancing learning and memory.
PQQ can promote the synthesis of melatonin and improve sleep quality by increasing melatonin levels.
What is Coenzyme Q10(CoQ10)?
Coenzyme Q10 (CoQ10), also known as Ubiquinone (UQ) or Coenzyme Q (CoQ), is a coenzyme present in all eukaryotic organisms involved in aerobic respiration.
It is a benzoquinone lipid-soluble compound with a structure similar to vitamin K and vitamin E. Q represents the quinone group, and 10 represents the number of isoprene units attached to its tail. It is a naturally occurring antioxidant in the human body, widely present in our cells, especially in high-energy-demanding organs such as the heart, liver, and kidneys.
CoQ10 is widely present in many organs of the human body, such as the heart, liver, and kidneys, with the highest concentration in the heart. It is crucial for maintaining heart function and has antioxidant and immune-enhancing properties.
In addition, studies have shown that coenzyme Q10 can also reduce the levels of pro-inflammatory cytokines and has certain anti-inflammatory effects.
What does Coenzyme Q10(CoQ10) do for the body
1. Assist in the production of ATP
Everyone knows that mitochondria are organelles in the body’s cells that produce energy. Through the intake of nutrients from the outside, we ultimately synthesize adenosine triphosphate (ATP) in mitochondria.ATP provides energy to our body and participates in regulating metabolic activities, maintaining the normal functioning of living systems.
Coenzyme Q10 plays an important role in the human body, as it can promote ATP production, enhance cell vitality, improve fatigue, and is particularly suitable for high-energy consuming organs.
2. Eliminate free radicals and antioxidants
Free radicals are widely present in nature and human activities, but their excessive generation can lead to oxidative stress, damage cells, and ultimately trigger various diseases.
Coenzyme Q10 can prevent lipid and protein peroxidation, eliminate free radicals, and reduce oxidative stress. Protect cell membranes from oxidative damage. Its antioxidant capacity is 2-3 times that of vitamin E.
3. Protecting Heart Health
Coenzyme Q10 has a relatively high content in the myocardium. When it is lacking, it can cause insufficient cardiac function, leading to poor blood circulation, decreased cardiac function, and ultimately, heart disease.
The main function of coenzyme Q10 on the myocardium is to promote cellular oxidative phosphorylation, improve myocardial energy metabolism, and alleviate ischemic damage to the myocardium; Increase the output of cardiac blood; improve chronic congestion and anti-arrhythmic effects can protect the myocardium, improve heart function, and provide sufficient energy for the myocardium.
4. Improve cognitive and neurological health
Besides the heart, the brain is the most active and high-energy-demanding organ in the human body. The brain has a high demand for oxygen and is highly susceptible to oxidative damage, which increases the production of harmful compounds and affects memory, cognition, and bodily functions. The decrease in mitochondrial energy production can also trigger migraines,
Coenzyme Q10 can provide sufficient oxygen and energy to brain cells, improve mitochondrial energy metabolism, and maintain healthy and active brain and nerve cells. It plays an important role in the health of our nervous system.
The synergistic effect of PQQ and CoQ10
1. Improved mitochondrial efficiency
PQQ, as a key coenzyme in mitochondrial biosynthesis, can promote mitochondrial regeneration and repair, increase mitochondrial quantity and quality, thereby enhancing cellular energy metabolism. Coenzyme Q10, as the core component of the electron transport chain, directly participates in the generation of ATP, ensuring the smooth progress of energy conversion.
The combination of the two can optimize mitochondrial membrane potential, enhance respiratory chain enzyme activity, and significantly improve fatigue and physical endurance.
2. Energy support for the nervous system
PQQ improves cognitive function by regulating the release of neurotransmitters such as dopamine and serotonin. Coenzyme Q10 provides stable energy to nerve cells, enhances cerebral blood flow, and provides neuroprotection. Both can slow down the progression of neurodegenerative diseases such as Alzheimer’s disease.
3. Free radical scavenging and oxidative stress inhibition
PQQ has strong free radical scavenging ability, can neutralize reactive oxygen species (ROS), and reduce DNA and mitochondrial damage. Coenzyme Q10, as a lipid-soluble antioxidant, can inhibit lipid peroxidation and protect cell membranes and low-density lipoprotein (LDL) from oxidative damage.
Both can enhance antioxidant capacity, delay cellular aging, and reduce aging phenomena such as skin wrinkles and pigmentation.
4. Myocardial function and vascular protection
Coenzyme Q10 is a core component of myocardial cell energy metabolism, which can improve cardiac output and reduce the risk of arrhythmia in patients with heart failure. PQQ can reduce blood pressure, regulate blood lipids, and delay atherosclerosis by reducing myocardial oxidative damage and improving vascular endothelial function in cooperation with coenzyme Q10.
Coenzyme Q10 reduces blood viscosity, PQQ promotes vascular elasticity, and the combination of the two can optimize systemic blood circulation, prevent cerebral ischemia, and thrombosis.
5. Anti-aging
The decline of mitochondrial function is the core mechanism of aging. PQQ stimulates mitochondrial regeneration, while coenzyme Q10 maintains its energy metabolism efficiency. The synergy between the two can restore the youthful structure of mitochondria and reduce age-related functional degradation.
Where to buy PQQ and CoQ10?
Runtai Chemical is a professional and reliable Chinese manufacturer of Pyrroloquinoline quinone(PQQ) and Coenzyme Q10 (CoQ10) with higher purity and lower price for 15 years. If you are interested in our Pyrroloquinoline quinone(PQQ), feel free to contact us for free samples!
