What is L-tyrosine（CAS 60-18-4）?
L-tyrosine is an aromatic amino acid produced by phenylalanine metabolism in the human body. Plays a crucial role in biological functions, particularly in the synthesis of proteins and key neurochemicals.
Definition and Biological Role
L-Tyrosine（CAS 60-18-4） is synthesized in the body from another essential amino acid, L-phenylalanine (PHE), through a process called hydroxylation, which occurs primarily in the liver. Because the body can produce it, it’s typically categorized as non-essential. However, for individuals who cannot properly metabolize L-phenylalanine (such as those with Phenylketonuria, or PKU), tyrosine must be supplemented, making it conditionally essential.
- Building Block: It is incorporated into proteins across the body.
- Precursor Role: Its most important biological function is serving as a precursor for several crucial compounds, including:
- Neurotransmitters: Dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline).
- Hormones: Thyroid hormones and melanin (the pigment responsible for skin and hair color).
Chemical Properties
- Chemical name： L-tyrosine
- CAS：60-18-4
- Molecular Formula: C9H11NO3
- Structure: It possesses an aromatic side chain consisting of a benzene ring with a hydroxyl group attached, which is key to its role in neurotransmitter synthesis.
- Polarity: Considered polar due to the presence of the hydroxyl group on the aromatic ring.
- Hydrophilic/Hydrophobic: While the aromatic ring is hydrophobic, the terminal hydroxyl group makes the side chain moderately hydrophilic (water-soluble). This mixed character allows it to exist both on the surface and within the folds of proteins.
- Classification: It is one of the three aromatic amino acids (along with Phenylalanine and Tryptophan).
Natural Food Sources of L-Tyrosine
Health Benefits of L-Tyrosine
1. Participate in neurotransmitter synthesis
It is an important precursor for the synthesis of dopamine, adrenaline, and norepinephrine. These neurotransmitters play a crucial role in regulating emotions, coping with stress, and enhancing memory and cognitive abilities.
2. Promote thyroid hormone synthesis
It is an important component of thyroid hormone synthesis, which is crucial for maintaining normal metabolism, heart function, and nervous system activity.
3. Improve emotions and stress resistance
It is a precursor of dopamine, norepinephrine, and adrenaline, which are closely related to emotion regulation, motivation, and stress response. Research has shown that supplementing L-tyrosine can alleviate stress-induced cognitive decline and improve mood swings and depressive symptoms, especially depression caused by dopamine deficiency
4. Enhance cognitive function and memory
It can enhance the brain’s focus, multitasking ability, and cognitive flexibility under stress by supporting neurotransmitter synthesis. Clinical trials have shown that supplementing with tyrosine can help alleviate attention loss after sleep deprivation or long-term work.
5. Enhance endurance and recovery
It helps maintain energy metabolism and prolong exercise endurance in high-intensity exercise or high-temperature environments by regulating adrenaline levels. Some studies suggest that acute supplementation of tyrosine (such as intake one hour before exercise) can improve exercise performance under high temperature conditions.
6. Combat sports fatigue
It reduces fatigue caused by long-term training by supporting neurotransmitter synthesis, especially suitable for athletes or high-intensity physical laborers.
7. Protect the skin and melanin production
It is a key raw material for melanin synthesis, which not only determines skin and hair color but also resists UV damage. Stable tyrosine levels help reduce hair whitening or hair loss caused by stress or aging.
8. Antioxidant and anti-aging
By supporting the synthesis of melatonin, tyrosine indirectly exerts antioxidant effects, reducing oxidative stress damage to the skin and cells
9. Assisted weight management and metabolism
It may suppress appetite and enhance fat metabolism by promoting dopamine secretion. In addition, it helps maintain basal metabolic rate by supporting thyroid function, but it requires a combination of diet and exercise to be effective
10. Immunity and Bone Health
It is involved in the absorption of iron and blood circulation, which may indirectly enhance immunity. Additionally, some studies suggest that tyrosine derivatives, such as L-tyrosyl-L-tyrosine, can support bone density and reduce the risk of osteoporosis by promoting calcium deposition and anti-inflammatory effects.
L-Tyrosine for Workouts & Fitness
L-Tyrosine supports workouts by boosting energy, endurance, and focus, especially under physical and mental stress. It helps replenish key neurotransmitters like dopamine and norepinephrine, which can be depleted during intense exercise, thus reducing fatigue and improving workout performance. Additionally, L-Tyrosine can promote fat metabolism and regulate overall energy balance, making it popular among bodybuilders and fitness enthusiasts as a pre-workout supplement.
L-Tyrosine Dosage and How to Take It
For those seeking to utilize L-Tyrosine supplements to support cognitive function, focus, or reduce the effects of stress, the correct dosage and timing are crucial to ensure optimal results.
How to Take It
The recommended dosage of L-Tyrosine typically ranges from 500 to 2000 mg per dose. It is best taken 15 to 30 minutes before exercise or stressful activities for optimal effect. The onset of action usually occurs within 15 to 30 minutes. Dosage should be adjusted gradually according to individual tolerance and response due to variations among users.
In summary:
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Typical dose: 500–2000 mg per intake
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Best time: 15–30 minutes before exercise or stress
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Effect begins: 15–30 minutes after intake
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Note: Adjust dosage based on personal tolerance and needs
This regimen helps maximize cognitive and physical benefits while minimizing any side effects.
Precautions
Use on an empty stomach: It is recommended to take L-tyrosine on an empty stomach or with a low-protein meal. Consuming large amounts of protein with L-tyrosine may cause it to compete with other amino acids for access to the brain, reducing its effectiveness.
Combining with other nutrients: The conversion of L-tyrosine into neurotransmitters requires the participation of coenzymes such as vitamin B6 and folic acid. Ensuring these nutrients will help improve tyrosine utilization.
Potential Side Effects: L-tyrosine is generally well-tolerated at recommended doses. Excessive intake may cause mild side effects such as headache, nausea, or stomach upset.
Where to Buy High-Purity L-Tyrosine powder （CAS 60-18-4）in Bulk?
- Runtai Chemical has over 15 years of international export experience and is well-versed in global transportation and quality certification standards. No matter where your factory is located, we can ensure that the raw materials arrive safely, quickly, and in compliance with regulations.
- We provide high-purity (USP/EP grade) L-Tyrosine raw material that meets international pharmaceutical and food standards. As a direct manufacturer, we offer competitive factory-source pricing, effectively reducing your production costs.
- We specialize in meeting the needs of corporate clients, offering flexible purchasing options from kilograms to tons. We also provide complete COA (Certificate of Analysis) and other relevant quality and regulatory documentation.
- We have large-scale supply capabilities and a stable and reliable supply chain. This is crucial for large brands that require continuous supply, ensuring that you can get timely replenishment of raw materials even during peak market demand.
Conclusion
L-Tyrosine is a versatile amino acid with significant benefits for both mental focus and physical performance, especially in stressful or demanding situations. It supports neurotransmitter production, mood regulation, and exercise endurance, making it valuable in sports nutrition and overall health.
For businesses seeking high-purity L-Tyrosine in bulk, Runtai Chemical offers competitive pricing, reliable supply, and free sample support. Contact Runtai Chemical to explore quality L-Tyrosine for your formulation needs and elevate your product lineup.
FAQs About L-Tyrosine（CAS 60-18-4）
Is L-tyrosine polar or nonpolar?
L-Tyrosine is considered a polar amino acid because its structure contains a phenolic hydroxyl group that provides polarity. However, it also has a hydrophobic benzene ring, which makes it partially nonpolar in certain interactions.
Is tyrosine hydrophobic or hydrophilic?
L-Tyrosine shows both properties. It is hydrophilic due to its hydroxyl group, but also has hydrophobic characteristics from its aromatic ring. Its solubility depends on pH conditions, which is why pure L-tyrosine powder has limited water solubility.
Can you take L-tyrosine and L-theanine together?
Yes. L-Tyrosine and L-Theanine can be taken together, and some people combine them for enhanced focus, stress reduction, and balanced mood. Dosage control is important, and it is best to follow professional advice when stacking supplements.
Can L-tyrosine help with weight loss?
L-Tyrosine may support weight loss indirectly by boosting dopamine and norepinephrine production, which can regulate appetite, improve motivation, and increase fat metabolism. While not a direct fat burner, combining tyrosine supplementation with exercise and diet may enhance overall results.
L-tyrosine powder is a convenient supplement form widely used in fitness, cognitive health, and nutritional applications. It can be mixed into drinks, capsules, or functional foods to support neurotransmitter production, stress resistance, and mental focus. In sports nutrition, many athletes prefer L-tyrosine powder for its fast absorption and flexibility in dosage adjustment.
