O-Cresolphthalein with CAS 596-27-0
What is O-Cresolphthalein?
O-Cresolphthalein (CAS 596-27-0) is a phthalein-type pH indicator and metal ion chelating agent widely used in analytical and clinical chemistry. It belongs to the family of phenolphthalein derivatives, distinguished by two ortho-cresol substituents that enhance its sensitivity to calcium and magnesium ions.
In its free acid form, O-Cresolphthalein appears as a white crystalline powder. In alkaline solution (pH 8.2–9.8), it transitions from colorless to a vivid red-purple, making it an excellent visual indicator for acid-base titrations and calcium detection in biological fluids.
O-Cresolphthalein Complexone (also known as O-Cresolphthalein Complexon or OCPC) is its chelating derivative, widely adopted in clinical chemistry analyzers for automated serum calcium determination. This form is one of the most globally standardized reagents for calcium measurement in hospital laboratories.
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Product Advantages
- High Sensitivity & Precision: Exhibits sharp, well-defined color transitions at pH 8.2–9.8 with minimal background interference, enabling accurate endpoint detection in both manual and automated analyses.
- Broad Solvent Compatibility: Soluble in ethanol, DMSO, and dilute alkaline solutions. Practically insoluble in water as free acid, enabling versatile formulation for various buffer systems and reagent kits.
- Flexible Packaging & Scale: Available from gram lab quantities to multi-kilogram bulk orders. Packed light-resistant containers to preserve stability during long-distance shipping.
- Global Export Experience: Full export documentation — COA, MSDS, test reports, shipping declarations. Experienced in regulatory compliance for US, EU, and South American import requirements.
O-Cresolphthalein Quick details
- Chemical Name:O-Cresolphthalein
- CAS No.: 596-27-0
- EINECS: 209-881-8
- Molecular Formula: C22H18O4
- Molecular weight: 346.38
- Appearance:white powder
- Purity:99%
- Synonyms:3’,3’’-dimethyl-phenolphthalei;cresolphthalein;Di-o-Cresolphthalide;o-Cresolphalein;o-cresolphtaleine;3,3-bis(4-hydroxy-3-methylphenyl)-Chemicalbook(3H)-Isobenzofuranone;3,3-bis(4-hydroxy-3-methylphenyl)-1(3h)-isobenzofuranon;3,3-Bis(4-hydroxy-3-methylphenyl)-1-(3H)-iso-benzofuranone
O-Cresolphthalein Typical Properties
| Item | Specification | Results |
| Appearance | White Powder | Conforms |
| Assay | ≥99% | 99.62% |
| PH color changing domain | 8.2(colorless)-9.8（red） | Conforms |
| Ethanol solubility test | Pass | Pass |
| Conclusion | The results conforms with enterprise standards | |
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O-Cresolphthalein Applications
- Acid-Base Titration Indicator: Used as a visual pH indicator in volumetric analysis for strong acid–strong base and weak acid–strong base titrations. The sharp colorless-to-red transition at approximately pH 8.2–9.8 provides a clear, unambiguous endpoint signal in aqueous systems.
- Complexometric Titration: Serves as a metallochromic indicator in EDTA-based complexometric titrations for calcium and magnesium hardness analysis in water quality testing. Widely employed in environmental labs and industrial water treatment monitoring programs.
- Educational & Laboratory Teaching: A staple indicator in university analytical chemistry laboratories. Its vivid color change, predictable pKa behavior, and safety profile make it ideal for teaching titration techniques and demonstrating pH-dependent molecular transformations.
O-Cresolphthalein Package & Storage
- Package: 25kg/drum
- Storage: Store in a cool place and keep it sealed to avoid direct sunlight.
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